%PDF-1.6
%
5 0 obj
<>>>/BBox[0 0 612 792]/Length 80>>stream
xs
w3T04PI2P0T5T R
ƦzƆ
!\nE
Ey9
ũ
y9z
!Y\ ] 5 j
endstream
endobj
1 0 obj
<>>>/BBox[0 0 612 792]/Length 134>>stream
x=0=F|
T֦)"m^I7Y;nxVȓVPXi22NbQp!GS}!袟}L.~9?j-zQ"Lm
&8
endstream
endobj
13 0 obj
<>>>/BBox[0 0 612 792]/Length 80>>stream
xs
w3T04PI2P0T5T R
ƦzƆ
!\nE
Ey9
ũ
y9z
!Y\ ] 5 j
endstream
endobj
12 0 obj
<>>>/BBox[0 0 612 792]/Length 134>>stream
x=0=F|
T֦)"m^I7Y;nxVȓVPXi22NbQp!GS}!袟}L.~9?j-zQ"Lm
&8
endstream
endobj
10 0 obj
<>>>/BBox[0 0 612 792]/Length 134>>stream
x=0=F|
T֦)"m^I7Y;nxVȓVPXi22NbQp!GS}!袟}L.~9?j-zQ"Lm
&8
endstream
endobj
11 0 obj
<>>>/BBox[0 0 612 792]/Length 80>>stream
xs
w3T04PI2P0T5T R
ƦzƆ
!\nE
Ey9
ũ
y9z
!Y\ ] 5 j
endstream
endobj
6 0 obj
<>>>/BBox[0 0 612 792]/Length 134>>stream
x=0=F|
T֦)"m^I7Y;nxVȓVPXi22NbQp!GS}!袟}L.~9?j-zQ"Lm
&8
endstream
endobj
3 0 obj
<>>>/BBox[0 0 612 792]/Length 80>>stream
xs
w3T04PI2P0T5T R
ƦzƆ
!\nE
Ey9
ũ
y9z
!Y\ ] 5 j
endstream
endobj
9 0 obj
<>>>/BBox[0 0 612 792]/Length 80>>stream
xs
w3T04PI2P0T5T R
ƦzƆ
!\nE
Ey9
ũ
y9z
!Y\ ] 5 j
endstream
endobj
4 0 obj
<>>>/BBox[0 0 612 792]/Length 134>>stream
x=0=F|
T֦)"m^I7Y;nxVȓVPXi22NbQp!GS}!袟}L.~9?j-zQ"Lm
&8
endstream
endobj
7 0 obj
<>>>/BBox[0 0 612 792]/Length 80>>stream
xs
w3T04PI2P0T5T R
ƦzƆ
!\nE
Ey9
ũ
y9z
!Y\ ] 5 j
endstream
endobj
8 0 obj
<>>>/BBox[0 0 612 792]/Length 134>>stream
x=0=F|
T֦)"m^I7Y;nxVȓVPXi22NbQp!GS}!袟}L.~9?j-zQ"Lm
&8
endstream
endobj
15 0 obj
<>stream
2016-03-22T09:47:04-07:00
2007-10-03T13:10:15-07:00
2016-03-22T09:47:04-07:00
Adobe Acrobat 7.0
application/pdf
uuid:6eef5f69-c756-400a-bbf2-290b0676fb90
uuid:a988ea82-8c61-4467-afe7-18f5a6d36ba0
Adobe Acrobat 7.0 Paper Capture Plug-in; modified using iText 4.2.0 by 1T3XT
endstream
endobj
16 0 obj
<>stream
x+ |
endstream
endobj
17 0 obj
<>stream
xS**T0T0 BiU"
endstream
endobj
18 0 obj
<>stream
x+ |
endstream
endobj
19 0 obj
<>stream
xS**T0T0 BiU"
endstream
endobj
20 0 obj
<>stream
x+ |
endstream
endobj
21 0 obj
<>stream
xS**T0T0 Bih]"
W
endstream
endobj
22 0 obj
<>stream
x+ |
endstream
endobj
23 0 obj
<>stream
xS**T0T0 BiU"
endstream
endobj
24 0 obj
<>stream
x+ |
endstream
endobj
25 0 obj
<>stream
xS**T0T0 BiU" `
endstream
endobj
26 0 obj
<>stream
x+ |
endstream
endobj
27 0 obj
<>stream
xS**T0T0 BiU" n
endstream
endobj
29 0 obj
<>stream
q
612 0 0 792 0 0 cm
/Im0 Do
Q
q
0.204 g
458.8800049 0 0 613.4400024 26.8800049 147.8399963 cm
/Im1 Do
Q
0 0 0 rg
1 i
BT
/T1_0 1 Tf
0 Tc 0 Tw 0 Ts 100 Tz 3 Tr 8.25 0 0 8.375 29.2797 755.0398 Tm
(2332 )Tj
/T1_1 1 Tf
0.0714 Tc 7 0 0 7.5 202.0803 753.8401 Tm
(CAN. )Tj
/T1_0 1 Tf
0.0862 Tc 7.25 0 0 7.5 224.4001 753.8401 Tm
(J, )Tj
/T1_1 1 Tf
0.0179 Tc 7 0 0 7.75 233.2804 753.8401 Tm
(ZOOL. )Tj
/T1_0 1 Tf
0.0164 Tc 7.625 0 0 7.625 259.6805 753.8401 Tm
(VOL. )Tj
/T1_2 1 Tf
-0.0192 Tc 6.5 0 0 7.125 281.5203 753.8401 Tm
(57, )Tj
/T1_1 1 Tf
-0.0339 Tc 7.375 0 0 7.75 294.9598 753.8401 Tm
(1979 )Tj
/T1_0 1 Tf
0 Tc 10.75 0 0 10.375 28.08 732.2399 Tm
(topine )Tj
2.88 0 Td
[(is )-88(produced )]TJ
-0.0349 Tc 5.157 0 Td
(by )Tj
0.0116 Tc 1.362 0 Td
(the )Tj
0 Tc 1.63 0 Td
[(muscle )-110(in )]TJ
-0.0116 Tc 4.287 0 Td
(high )Tj
0.0116 Tc 2.076 0 Td
(concen- )Tj
-17.392 -1.041 Td
(trations )Tj
0 Tc 3.416 0 Td
(during )Tj
0.0233 Tc 2.902 0 Td
(work, )Tj
-0.0116 Tc 2.701 0 Td
(is )Tj
0.0116 Tc 0.893 0 Td
(found )Tj
-0.0233 Tc 2.701 0 Td
(in )Tj
0.0116 Tc 1.049 0 Td
[(elevated )-42(concen- )]TJ
-13.663 -1.087 Td
(trations )Tj
-0.0233 Tc 3.304 0 Td
(in )Tj
0.0116 Tc 0.982 0 Td
(the )Tj
0 Tc 1.451 0 Td
[(blood )5(during )]TJ
0.0233 Tc 5.336 0 Td
(recovery, )Tj
0 Tc 4.197 0 Td
(and )Tj
-0.0116 Tc 1.674 0 Td
(is )Tj
0 Tc 0.848 0 Td
(readily )Tj
0.0116 Tc -17.816 -1.018 Td
(taken )Tj
0 Tc 2.59 0 Td
[(up )-67(from )]TJ
0.0116 Tc 3.617 0 Td
[(the )-67(bloodstream )]TJ
0.0233 Tc 7.01 0 Td
(and )Tj
0 Tc 1.831 0 Td
(oxidized )Tj
-0.0116 Tc 3.795 0 Td
(by )Tj
0.0116 Tc 1.34 0 Td
(a )Tj
-20.182 -1.064 Td
(variety )Tj
0 Tc 3.304 0 Td
(of )Tj
0.0233 Tc 1.228 0 Td
(other )Tj
0.0116 Tc 2.545 0 Td
(tissues )Tj
0 Tc 3.193 0 Td
[(including )-147(brain )]TJ
0.0116 Tc 6.675 0 Td
[(and )-157(ven- )]TJ
-16.945 -1.064 Td
(tricle. )Tj
0 Tc 2.791 0 Td
(Tissue-specific )Tj
0.0116 Tc 6.407 0 Td
(isozymes )Tj
-0.0233 Tc 4.13 0 Td
(of )Tj
0.0116 Tc 1.139 0 Td
(octopine )Tj
0.0233 Tc 3.862 0 Td
(dehy- )Tj
0.0116 Tc -18.307 -1.041 Td
(drogenase )Tj
0.0233 Tc 4.51 0 Td
(occur )Tj
0.0116 Tc 2.657 0 Td
(\(Storey )Tj
/T1_1 1 Tf
-0.0123 Tc 10.125 0 0 10.625 142.3202 666.7196 Tm
(1977; )Tj
/T1_0 1 Tf
0.0233 Tc 10.75 0 0 10.375 168.2402 666.7196 Tm
(Storey )Tj
0.0116 Tc 3.036 0 Td
[(and )-112(Storey )]TJ
/T1_1 1 Tf
0 Tc 10.125 0 0 10.625 29.0402 655.6805 Tm
(19796\). )Tj
/T1_0 1 Tf
0.0233 Tc 10.75 0 0 10.375 63.1198 655.6805 Tm
(The )Tj
0 Tc 1.875 0 Td
(muscle )Tj
0.0116 Tc 3.103 0 Td
(isozyme )Tj
0.0233 Tc 3.639 0 Td
(appears )Tj
0.0116 Tc 3.416 0 Td
(geared )Tj
0 Tc 3.014 0 Td
(to )Tj
0.0116 Tc 1.049 0 Td
(the )Tj
0 Tc -19.312 -1.041 Td
(rapid )Tj
0.0116 Tc 2.367 0 Td
(synthesis )Tj
-0.0465 Tc 4.041 0 Td
(of )Tj
0.0116 Tc 1.027 0 Td
(octopine )Tj
0 Tc 3.795 0 Td
[(during )3(glycolytic )]TJ
0.0116 Tc 7.1 0 Td
(activ- )Tj
0.0233 Tc -18.307 -1.041 Td
(ity, )Tj
0.0116 Tc 1.607 0 Td
(whereas )Tj
0.0233 Tc 3.617 0 Td
(the )Tj
0 Tc 1.518 0 Td
[(brain )-39(specific )]TJ
0.0116 Tc 5.626 0 Td
(isozyme )Tj
0 Tc 3.639 0 Td
(has )Tj
0.0116 Tc 1.585 0 Td
(proper- )Tj
0 Tc -17.57 -1.041 Td
[(ties )-80(closely )-132(resembling )]TJ
0.0116 Tc 9.712 0 Td
(those )Tj
-0.0233 Tc 2.545 0 Td
(of )Tj
0.0116 Tc 1.161 0 Td
(the )Tj
0 Tc 11 0 0 10.875 190.5601 623.2797 Tm
(H )Tj
0.0116 Tc 10.75 0 0 10.375 202.0803 623.2797 Tm
(isozyme )Tj
-0.0465 Tc 3.706 0 Td
(of )Tj
0.0233 Tc -19.847 -1.064 Td
(lactate )Tj
0.0116 Tc 2.925 0 Td
[(dehydrogenase )48(and )]TJ
0.0233 Tc 8.015 0 Td
(appears )Tj
-0.0349 Tc 3.393 0 Td
(well )Tj
0 Tc 1.898 0 Td
(suited )Tj
0.0233 Tc 2.59 0 Td
(for )Tj
0.0116 Tc 1.384 0 Td
(a )Tj
-20.227 -1.041 Td
(function )Tj
-0.0233 Tc 3.706 0 Td
(in )Tj
0.0116 Tc 1.027 0 Td
[(octopine )3(oxidation. )]TJ
0.0233 Tc 8.305 0 Td
(Thus )Tj
0.0116 Tc 2.344 0 Td
(there )Tj
-0.0116 Tc 2.367 0 Td
(is )Tj
0 Tc 0.893 0 Td
(good )Tj
0.0116 Tc -18.62 -1.064 Td
(evidence )Tj
0.0465 Tc 3.952 0 Td
(to )Tj
0 Tc 1.139 0 Td
(suggest )Tj
0.0233 Tc 3.282 0 Td
(that )Tj
0 Tc 1.898 0 Td
(muscle )Tj
0.0116 Tc 3.17 0 Td
(octopine, )Tj
0 Tc 4.13 0 Td
(like )Tj
0.0116 Tc 1.808 0 Td
(the )Tj
-19.379 -1.064 Td
[(lactate )-150(produced )]TJ
0 Tc 7.345 0 Td
(during )Tj
0.0233 Tc 3.036 0 Td
(vertebrate )Tj
0 Tc 4.599 0 Td
(muscle )Tj
0.0233 Tc 3.26 0 Td
(work, )Tj
0 Tc -18.24 -1.064 Td
(could )Tj
-0.0116 Tc 2.701 0 Td
(be )Tj
0.0116 Tc 1.384 0 Td
(an )Tj
0 Tc 1.384 0 Td
(effective )Tj
0.0233 Tc 3.974 0 Td
[(substrate )-93(for )]TJ
0.0116 Tc 5.76 0 Td
(aerobic )Tj
0.0233 Tc 3.438 0 Td
(cata- )Tj
-0.0116 Tc -18.642 -1.041 Td
(bolism )Tj
0.0465 Tc 2.88 0 Td
(or )Tj
0.0116 Tc 1.049 0 Td
(for )Tj
0 Tc 1.384 0 Td
(gluconeogenesis )Tj
-0.0465 Tc 6.787 0 Td
(in )Tj
0.0116 Tc 0.96 0 Td
(other )Tj
0 Tc 2.322 0 Td
[(body )-5(tissues. )]TJ
0.0233 Tc -14.467 -1.041 Td
(In )Tj
0.0116 Tc 1.139 0 Td
(the )Tj
0.0233 Tc 1.54 0 Td
(present )Tj
0.0116 Tc 3.326 0 Td
(study )Tj
-0.0116 Tc 2.5 0 Td
(we )Tj
0.0116 Tc 1.429 0 Td
[(have )-36(examined )]TJ
0.0233 Tc 6.452 0 Td
(the )Tj
0 Tc 1.541 0 Td
(time )Tj
0.0233 Tc -18.843 -1.064 Td
(course )Tj
-0.0233 Tc 2.969 0 Td
(of )Tj
0 Tc 1.094 0 Td
(changes )Tj
-0.0465 Tc 3.527 0 Td
(in )Tj
0 Tc 1.027 0 Td
(blood )Tj
0.0116 Tc 2.545 0 Td
[(octopine )-19(concentration )]TJ
0 Tc -11.163 -1.018 Td
[(during )-86(hypoxia )]TJ
0.0116 Tc 6.541 0 Td
[(and )-90(recovery )]TJ
0 Tc 5.827 0 Td
[(with )-115(the )]TJ
0.0116 Tc 3.706 0 Td
(aims )Tj
-0.0233 Tc 2.233 0 Td
(of )Tj
0.0116 Tc 1.161 0 Td
(es- )Tj
0 Tc -19.468 -1.087 Td
(tablishing )Tj
0.0233 Tc 4.108 0 Td
[(the )136(pattern )]TJ
0.0116 Tc 4.554 0 Td
(and )Tj
0.0233 Tc 1.652 0 Td
(extent )Tj
-0.0465 Tc 2.746 0 Td
(of )Tj
0.0116 Tc 1.005 0 Td
[(octopine )115(release )]TJ
0 Tc -14.11 -1.041 Td
(from )Tj
0.0116 Tc 2.411 0 Td
[(the )-178(muscle. )-213(Experimental )]TJ
0 Tc 11.274 0 Td
(manipulations )Tj
-0.0233 Tc 6.162 0 Td
(of )Tj
0 Tc -19.825 -1.064 Td
(blood )Tj
0.0116 Tc 2.634 0 Td
[(octopine )-41(levels )-37(were )-71(also )-23(used )]TJ
0.0233 Tc 13.038 0 Td
(to )Tj
0.0116 Tc 1.139 0 Td
[(study )-81(the )]TJ
-16.811 -1.041 Td
(rate )Tj
-0.0465 Tc 1.965 0 Td
(of )Tj
0.0116 Tc 1.183 0 Td
[(octopine )-131(clearance )]TJ
0 Tc 8.171 0 Td
(from )Tj
0.0116 Tc 2.367 0 Td
(the )Tj
0 Tc 1.607 0 Td
(blood )Tj
0.0116 Tc 2.679 0 Td
(and )Tj
0.0233 Tc 1.875 0 Td
(to )Tj
0.0116 Tc -19.848 -1.064 Td
[(determine )12(the )]TJ
0 Tc 5.849 0 Td
(relationship )Tj
0.0116 Tc 5.023 0 Td
(between )Tj
0 Tc 3.706 0 Td
(blood )Tj
0.0116 Tc 2.523 0 Td
(octopine )Tj
-17.101 -1.041 Td
(concentration )Tj
0 Tc 6.296 0 Td
(and )Tj
0.0116 Tc 2.121 0 Td
[(the )-401(concentrations )]TJ
-0.0465 Tc 8.618 0 Td
(of )Tj
0.0233 Tc 1.451 0 Td
(other )Tj
0 Tc -18.508 -1.064 Td
(blood )Tj
0.0116 Tc 2.657 0 Td
(metabolites, )Tj
0 Tc 5.358 0 Td
[(most )-104(notably )]TJ
0.0116 Tc 5.693 0 Td
(glucose. )Tj
0.0233 Tc 3.751 0 Td
(The )Tj
0 Tc 1.92 0 Td
(ex- )Tj
0.0116 Tc -19.401 -1.041 Td
[(periments )-155(demonstrated )]TJ
0 Tc 10.471 0 Td
(that )Tj
0.0116 Tc 1.92 0 Td
[(octopine )-131(concentra- )]TJ
0 Tc -12.346 -1.064 Td
(tion )Tj
-0.0233 Tc 1.875 0 Td
(in )Tj
0.0116 Tc 1.072 0 Td
(the )Tj
-0.0116 Tc 1.585 0 Td
(blood )Tj
0 Tc 2.634 0 Td
(was )Tj
0.0116 Tc 1.853 0 Td
(elevated )Tj
0 Tc 3.773 0 Td
[(during )-64(hypoxia )-100(but )]TJ
0.0116 Tc -12.815 -1.064 Td
(octopine )Tj
0 Tc 3.974 0 Td
(rapidly )Tj
0.0116 Tc 3.326 0 Td
(returned )Tj
0.0233 Tc 3.907 0 Td
(to )Tj
0.0116 Tc 1.25 0 Td
(control )Tj
0 Tc 3.349 0 Td
[(levels )-208(upon )]TJ
0.0116 Tc -15.784 -1.041 Td
(return )Tj
0.0465 Tc 2.724 0 Td
(to )Tj
0 Tc 1.049 0 Td
(normoxic )Tj
0.0233 Tc 4.153 0 Td
(water. )Tj
0.0116 Tc 2.88 0 Td
(Experimental )Tj
0 Tc 5.782 0 Td
(manipula- )Tj
-16.61 -1.041 Td
(tion )Tj
-0.0233 Tc 1.898 0 Td
(of )Tj
0 Tc 1.139 0 Td
(blood )Tj
0.0116 Tc 2.634 0 Td
[(octopine )-41(concentration )-150(resulted )]TJ
-0.0233 Tc 13.418 0 Td
(in )Tj
0.0116 Tc 1.094 0 Td
(a )Tj
-20.205 -1.064 Td
(transient )Tj
0 Tc 3.974 0 Td
(rise )Tj
-0.0233 Tc 1.853 0 Td
(in )Tj
0 Tc 1.116 0 Td
(blood )Tj
0.0116 Tc 2.657 0 Td
[(glucose )-62(during )]TJ
0.0233 Tc 6.452 0 Td
(the )Tj
-0.0116 Tc 1.674 0 Td
(time )Tj
-0.0233 Tc 2.121 0 Td
(of )Tj
0.0116 Tc -19.825 -1.041 Td
[(octopine )-153(clearance. )-196(Additionally, )]TJ
0 Tc 14.378 0 Td
(blood )Tj
0.0116 Tc 2.724 0 Td
(octopine )Tj
-17.124 -1.087 Td
[(levels )30(were )]TJ
0 Tc 4.912 0 Td
(affected )Tj
-0.0116 Tc 3.527 0 Td
(by )Tj
0.0233 Tc 1.295 0 Td
(the )Tj
0.0116 Tc 1.541 0 Td
[(experimental )-4(elevation )]TJ
-0.0233 Tc -11.274 -1.041 Td
(of )Tj
0.0116 Tc 1.049 0 Td
[(the )45(concentrations )]TJ
-0.0233 Tc 7.769 0 Td
(of )Tj
0 Tc 1.005 0 Td
[(blood )-17(arginine )]TJ
0.0116 Tc 6.05 0 Td
[(and )21(lactate. )]TJ
0 Tc -10.158 -1.827 Td
(Materials )Tj
0.0116 Tc 4.019 0 Td
(and )Tj
0 Tc 1.719 0 Td
(Methods )Tj
/T1_3 1 Tf
0.0476 Tc 7.875 0 0 8.25 27.5999 319.4396 Tm
[(Chemicals )154(and )]TJ
0.0318 Tc 6.766 0 Td
(Animals )Tj
/T1_0 1 Tf
0.0303 Tc 8.25 0 0 8.375 35.7605 310.3198 Tm
(Biochemicals )Tj
0.0152 Tc 6.196 0 Td
[(and )-253(coupling )]TJ
0.0303 Tc 6.109 0 Td
(enzymes )Tj
0.0455 Tc 4.218 0 Td
(were )Tj
0.0303 Tc 2.531 0 Td
[(purchased )-222(from )]TJ
-20.014 -1.06 Td
(Boehringer )Tj
0.0152 Tc 5.004 0 Td
(Mannheim )Tj
0.0303 Tc 4.713 0 Td
(Corp. )Tj
0.0455 Tc 2.647 0 Td
[(Octopine )194(and )]TJ
0.0152 Tc 5.876 0 Td
(arginine )Tj
0.0303 Tc 3.665 0 Td
(kinase )Tj
0.0455 Tc 2.909 0 Td
(were )Tj
0.0303 Tc -24.844 -1.06 Td
(from )Tj
0.0152 Tc 2.327 0 Td
(Sigma )Tj
0.0303 Tc 2.909 0 Td
(Chemical )Tj
0.0606 Tc 4.276 0 Td
(Co. )Tj
0.0455 Tc 1.833 0 Td
(In )Tj
0.0303 Tc 1.135 0 Td
(preparation )Tj
0.0455 Tc 5.236 0 Td
(for )Tj
0.0303 Tc 1.513 0 Td
[(cannulation )43(of )]TJ
0.0455 Tc 6.371 0 Td
(the )Tj
0.0303 Tc -25.571 -1.06 Td
[(cephalic )-131(vena )]TJ
0.0455 Tc 6.429 0 Td
(cava )Tj
0 Tc 2.444 0 Td
(with )Tj
0.0303 Tc 2.269 0 Td
(an )Tj
0.0152 Tc 1.455 0 Td
(indwelling )Tj
0.0303 Tc 4.829 0 Td
(polyethylene )Tj
0.0455 Tc 5.964 0 Td
(catheter )Tj
0.0303 Tc -23.418 -1.089 Td
(\(PE80\), )Tj
0.0152 Tc 3.404 0 Td
[(male )59(cuttlefish, )]TJ
/T1_3 1 Tf
0.0318 Tc 7.875 0 0 8.25 110.1599 274.5604 Tm
(Sepia )Tj
0.0635 Tc 2.712 0 Td
(oflcinalis )Tj
/T1_0 1 Tf
0 Tc 8.25 0 0 8.375 167.9996 274.5604 Tm
(\(1600-2800g\). )Tj
0.0303 Tc 6.255 0 Td
(were )Tj
0 Tc 2.24 0 Td
(im- )Tj
0.0303 Tc -25.513 -1.06 Td
(mersed )Tj
0 Tc 3.52 0 Td
(in )Tj
0.0152 Tc 1.193 0 Td
(ice-cold )Tj
0.0455 Tc 3.782 0 Td
(seawater. )Tj
0.0606 Tc 4.538 0 Td
(The )Tj
0.0152 Tc 2.124 0 Td
[(resulting )-171(muscle )]TJ
0.0303 Tc 7.476 0 Td
(relaxation )Tj
-22.662 -1.06 Td
(gave )Tj
0.0455 Tc 2.298 0 Td
[(access )9(to )]TJ
0.0303 Tc 4.247 0 Td
[(the )-36(cephalic )]TJ
0.0455 Tc 5.44 0 Td
[(vena )9(cava )]TJ
0.0303 Tc 4.655 0 Td
[(near )-59(the )]TJ
0.0455 Tc 3.753 0 Td
(anus )Tj
0.0303 Tc 2.298 0 Td
(where )Tj
0.0606 Tc 2.88 0 Td
(the )Tj
0.0303 Tc -25.542 -1.06 Td
(vessel )Tj
0.0455 Tc 3.229 0 Td
(runs )Tj
0.0152 Tc 2.502 0 Td
(superficially. )Tj
0.0455 Tc 6.167 0 Td
(The )Tj
0.0303 Tc 2.298 0 Td
[(vessel )-352(was )-314(cannulated )]TJ
0.0152 Tc 10.793 0 Td
(non- )Tj
0.0303 Tc -24.989 -1.06 Td
(obstructively )Tj
6.138 0 Td
(through )Tj
0.0152 Tc 3.811 0 Td
[(a )-294(small )]TJ
0.0303 Tc 3.753 0 Td
[(hole )-233(made )]TJ
0.0152 Tc 5.149 0 Td
(in )Tj
0.0455 Tc 1.309 0 Td
(the )Tj
0.0303 Tc 1.862 0 Td
(vessel )Tj
0 Tc 3.113 0 Td
(wall )Tj
0.0303 Tc -25.164 -1.089 Td
(percutaneously )Tj
0.0152 Tc 6.924 0 Td
[(by )-130(a )]TJ
0.0303 Tc 2.269 0 Td
(cutting-edge )Tj
0.0455 Tc 5.644 0 Td
(suture )Tj
0.0303 Tc 3.054 0 Td
(needle. )Tj
0.0606 Tc 3.491 0 Td
(The )Tj
0.0455 Tc 2.036 0 Td
(catheter )Tj
/T1_3 1 Tf
0.0318 Tc 7.875 0 0 8.25 261.5999 733.4396 Tm
[(Hypoxia )-80(Experiments )]TJ
/T1_0 1 Tf
0.0152 Tc 8.25 0 0 8.375 270.2395 724.3198 Tm
(Individual )Tj
0.0303 Tc 4.626 0 Td
[(animals )-4(were )]TJ
0.0152 Tc 5.964 0 Td
(placed )Tj
0.0455 Tc 3.113 0 Td
(one )Tj
0.0606 Tc 1.833 0 Td
(at )Tj
0.0152 Tc 1.105 0 Td
[(a )-90(time )]TJ
0 Tc 2.967 0 Td
(in )Tj
0.0152 Tc 1.105 0 Td
[(a )-61(small )]TJ
0.0303 Tc 3.316 0 Td
(tank )Tj
0.0152 Tc -25.018 -1.089 Td
(and )Tj
0.0455 Tc 1.775 0 Td
(the )Tj
/T1_3 1 Tf
0.0794 Tc 7.875 0 0 8.25 289.4403 715.2001 Tm
(Po, )Tj
/T1_0 1 Tf
0 Tc 8.25 0 0 8.375 303.5995 715.2001 Tm
(of )Tj
0.0455 Tc 1.047 0 Td
(the )Tj
0.0303 Tc 1.571 0 Td
(water )Tj
0.0152 Tc 2.589 0 Td
(lowered )Tj
0.0303 Tc 3.607 0 Td
(from )Tj
-0.0152 Tc 2.385 0 Td
(140 )Tj
0.0152 Tc 1.571 0 Td
(to )Tj
-0.0303 Tc 1.018 0 Td
(45 )Tj
0.0303 Tc 1.135 0 Td
(mmHg )Tj
3.113 0 Td
(\(1 )Tj
0.0152 Tc 0.96 0 Td
(mmHg )Tj
/T1_2 1 Tf
0 Tc 10.625 0 0 6.375 262.3195 706.5604 Tm
(= )Tj
/T1_0 1 Tf
8.25 0 0 8.375 272.1599 706.5604 Tm
(133.322 )Tj
0.0152 Tc 3.404 0 Td
(Pa\) )Tj
0 Tc 1.687 0 Td
(by )Tj
0.0152 Tc 1.309 0 Td
[(bubbling )-72(with )]TJ
0.0303 Tc 6.196 0 Td
(N2 )Tj
1.426 0 Td
(gas. )Tj
0.0455 Tc 2.065 0 Td
(The )Tj
0.0152 Tc 1.978 0 Td
(nitrogen )Tj
0.0303 Tc 3.811 0 Td
(was )Tj
0.0152 Tc 1.949 0 Td
(then )Tj
0.0303 Tc -25.047 -1.089 Td
(turned )Tj
-0.0152 Tc 3.229 0 Td
(off )Tj
0.0303 Tc 1.6 0 Td
[(and )-163(this )]TJ
0.0152 Tc 3.956 0 Td
(point )Tj
0.0303 Tc 2.618 0 Td
(designated )Tj
0.0758 Tc 5.004 0 Td
(as )Tj
0.0455 Tc 1.338 0 Td
(the )Tj
0.0303 Tc 1.804 0 Td
(start )Tj
0 Tc 2.327 0 Td
(of )Tj
0.0303 Tc 1.28 0 Td
(hypoxia. )Tj
-23.156 -1.06 Td
[(Hypoxia )-20(was )35(continued )]TJ
0.0455 Tc 10.298 0 Td
(for )Tj
-0.0303 Tc 1.484 0 Td
(45-75 )Tj
0 Tc 2.764 0 Td
(min )Tj
0.0303 Tc 1.833 0 Td
[(depending )64(on )]TJ
0.0606 Tc 5.935 0 Td
(the )Tj
0.0303 Tc 1.571 0 Td
(experi- )Tj
-23.855 -1.06 Td
(ment, )Tj
0.0455 Tc 2.676 0 Td
(after )Tj
0.0152 Tc 2.24 0 Td
(which )Tj
0.0303 Tc 2.793 0 Td
(animals )Tj
0.0455 Tc 3.52 0 Td
(were )Tj
0.0303 Tc 2.327 0 Td
(removed )Tj
0.0455 Tc 4.014 0 Td
(to )Tj
0.0303 Tc 1.135 0 Td
(normoxic )Tj
0.0455 Tc 4.276 0 Td
(water )Tj
0.0606 Tc 2.618 0 Td
(for )Tj
0.0455 Tc -25.629 -1.089 Td
(recovery. )Tj
0.0303 Tc 4.8 0 Td
[(Water )-354(and )]TJ
0.0152 Tc 5.44 0 Td
(blood )Tj
/T1_3 1 Tf
0.0476 Tc 7.875 0 0 8.25 371.2797 670.5604 Tm
(Po, )Tj
/T1_0 1 Tf
0.0303 Tc 8.25 0 0 8.375 388.7996 670.5604 Tm
[(were )-361(determined )]TJ
0.0152 Tc 8.145 0 Td
[(using )-401(a )]TJ
0.0303 Tc -23.534 -1.06 Td
(Radiometer )Tj
-0.0381 Tc 13.125 0 0 8.75 306 661.6802 Tm
(0, )Tj
0.0303 Tc 8.25 0 0 8.375 318.2399 661.6802 Tm
(electrode )Tj
0.0909 Tc 4.305 0 Td
(\(E )Tj
0 Tc 1.367 0 Td
(5045\) )Tj
0.0303 Tc 2.589 0 Td
(and )Tj
0.0152 Tc 1.92 0 Td
(a )Tj
0.0303 Tc 0.844 0 Td
(Radiometer )Tj
0.0455 Tc 5.353 0 Td
(PHM )Tj
-0.0152 Tc 2.647 0 Td
(72 )Tj
0.0152 Tc -25.833 -1.06 Td
(acid-base )Tj
0.0303 Tc 4.538 0 Td
(analyzer. )Tj
0.0152 Tc 4.218 0 Td
(Blood )Tj
0.0303 Tc 2.822 0 Td
(samples )Tj
0.0152 Tc 3.695 0 Td
(were )Tj
0.0303 Tc 2.298 0 Td
(taken )Tj
0.0606 Tc 2.589 0 Td
(at )Tj
0.0303 Tc 1.018 0 Td
[(intervals )70(dur- )]TJ
0 Tc -21.178 -1.089 Td
(ing )Tj
0.0303 Tc 1.542 0 Td
[(hypoxia )49(and )-18(recovery )-52(and )41(analyzed )]TJ
0.0606 Tc 15.418 0 Td
(for )Tj
0.0303 Tc 1.542 0 Td
[(metabolite )93(levels )]TJ
0.0455 Tc 7.476 0 Td
(as )Tj
0.0303 Tc -25.978 -1.06 Td
[(described )-153(below. )-189(Throughout )-135(hypoxia )]TJ
0.0455 Tc 17.193 0 Td
[(the )-121(seawater )]TJ
/T1_3 1 Tf
0.0318 Tc 7.875 0 0 8.25 452.8795 634.7999 Tm
(Po, )Tj
/T1_0 1 Tf
0.0303 Tc 8.25 0 0 8.375 468.4801 634.7999 Tm
(con- )Tj
0.0152 Tc -24.989 -1.089 Td
(tinued )Tj
0.0455 Tc 3.084 0 Td
(to )Tj
0.0303 Tc 1.309 0 Td
(decline )Tj
0.0152 Tc 3.52 0 Td
(slowly )Tj
3.2 0 Td
(\(Po,was )Tj
-0.0303 Tc 3.985 0 Td
(19-31 )Tj
0.0303 Tc 2.589 0 Td
(mmHg )Tj
0.0606 Tc 3.316 0 Td
(at )Tj
0.0303 Tc 1.251 0 Td
(the )Tj
0.0152 Tc 1.775 0 Td
(end )Tj
-0.0152 Tc 1.978 0 Td
(of )Tj
0.0303 Tc -26.065 -1.06 Td
[(hypoxia\) )92(and )41(the )51(animals, )73(although )]TJ
0.0152 Tc 15.04 0 Td
[(remaining )6(quiet )]TJ
0.0303 Tc 6.807 0 Td
(throughout, )Tj
-21.818 -1.032 Td
(showed )Tj
0 Tc 3.811 0 Td
[(signs )-283(of )]TJ
0.0303 Tc 3.956 0 Td
(distress. )Tj
0.0152 Tc 4.102 0 Td
(During )Tj
0.0455 Tc 3.462 0 Td
(the )Tj
0.0152 Tc 1.862 0 Td
(most )Tj
0.0303 Tc 2.589 0 Td
(severe )Tj
0.0455 Tc 3.258 0 Td
(phase )Tj
0 Tc 2.967 0 Td
(of )Tj
0.0303 Tc -26.036 -1.089 Td
(hypoxic )Tj
0.0455 Tc 3.665 0 Td
[(exposure, )143(venous )]TJ
/T1_3 1 Tf
0.0635 Tc 7.875 0 0 8.25 355.2001 599.0405 Tm
(Po, )Tj
/T1_0 1 Tf
0.0303 Tc 8.25 0 0 8.375 369.3604 599.0405 Tm
[(showed )85(values )]TJ
0.0152 Tc 6.4 0 Td
(matching )Tj
0.0455 Tc 4.073 0 Td
(those )Tj
0 Tc 2.531 0 Td
(of )Tj
0.0303 Tc -26.036 -1.06 Td
[(ambient )78(water )]TJ
0.0152 Tc 6.225 0 Td
(suggesting )Tj
0.0303 Tc 4.596 0 Td
(that )Tj
0.0606 Tc 1.833 0 Td
(no )Tj
-0.0476 Tc 13.125 0 0 8.75 376.5597 590.1603 Tm
(0, )Tj
0.0303 Tc 8.25 0 0 8.375 387.3604 590.1603 Tm
(was )Tj
0.0606 Tc 1.833 0 Td
[(takenupfrom )182(the )]TJ
0.0455 Tc 7.447 0 Td
(water )Tj
0.0606 Tc -24.494 -1.089 Td
(or )Tj
0.0152 Tc 1.105 0 Td
(utilized )Tj
0 Tc 3.404 0 Td
(by )Tj
0.0455 Tc 1.28 0 Td
(the )Tj
0.0303 Tc 1.571 0 Td
(tissues. )Tj
/T1_3 1 Tf
0.0476 Tc 7.875 0 0 8.25 261.3604 563.28 Tm
(Metabolite )Tj
0.0159 Tc 5.089 0 Td
(Bolus )Tj
0.0318 Tc 2.743 0 Td
(Experiments )Tj
/T1_0 1 Tf
0.0909 Tc 8.25 0 0 8.375 270 554.3998 Tm
(To )Tj
0.0303 Tc 1.396 0 Td
(experimentally )Tj
0.0152 Tc 6.633 0 Td
(raise )Tj
0.0303 Tc 2.269 0 Td
(the )Tj
0.0152 Tc 1.542 0 Td
(blood )Tj
0.0303 Tc 2.647 0 Td
(concentration )Tj
0 Tc 6.109 0 Td
(of )Tj
0.0152 Tc 1.076 0 Td
(a )Tj
0.0303 Tc 0.727 0 Td
(metabo- )Tj
0.0152 Tc -23.389 -1.06 Td
(lite, )Tj
0.0303 Tc 1.804 0 Td
[(animals )113(wereinjected )]TJ
0.0152 Tc 9.28 0 Td
[(via )49(the )]TJ
0.0303 Tc 2.938 0 Td
(chronically )Tj
0.0152 Tc 4.975 0 Td
(implanted )Tj
0.0455 Tc 4.393 0 Td
(catheter )Tj
0.0152 Tc -23.389 -1.089 Td
(with )Tj
0.0455 Tc 2.211 0 Td
(one )Tj
0 Tc 1.891 0 Td
(of )Tj
0.0455 Tc 1.193 0 Td
(three )Tj
0.0303 Tc 2.531 0 Td
[(loads )-17(\(each )]TJ
-0.0303 Tc 5.207 0 Td
(in )Tj
0.0152 Tc 1.134 0 Td
(3 )Tj
0.0606 Tc 0.669 -0 Td
(mL )Tj
0.0303 Tc 1.833 0 Td
(seawater\): )Tj
0 Tc 4.771 0 Td
(300 )Tj
1.629 0 Td
(pmol )Tj
0.0152 Tc 2.473 0 Td
(oc- )Tj
0.0303 Tc -25.542 -1.06 Td
(topine, )Tj
0 Tc 3.229 0 Td
(300 )Tj
0.3788 Tc 1.629 0 Td
(pol )Tj
0.2727 Tc 2.327 0 Td
(Na )Tj
0.0303 Tc 1.774 0 Td
(lactate, )Tj
0.0606 Tc 3.375 0 Td
(or )Tj
0 Tc 1.105 0 Td
(600 )Tj
1.658 0 Td
(pmol )Tj
0.0152 Tc 2.356 0 Td
[(L-arginine. )74(Infusion )]TJ
0 Tc 8.553 0 Td
(of )Tj
0.0455 Tc -26.036 -1.032 Td
(the )Tj
0.0303 Tc 1.775 0 Td
[(bolus )-194(was )]TJ
0.0152 Tc 4.829 0 Td
(followed )Tj
0 Tc 4.189 0 Td
(by )Tj
0.0758 Tc 1.484 0 Td
(0.5mL )Tj
0.0455 Tc 3.462 0 Td
(seawater )Tj
0.0152 Tc 4.247 0 Td
[(to )-177(flush )]TJ
0.0455 Tc 3.724 0 Td
(out )Tj
0.0303 Tc 1.862 0 Td
(the )Tj
0.0455 Tc -25.571 -1.089 Td
(catheter. )Tj
0.0152 Tc 4.044 0 Td
(Animals )Tj
0.0303 Tc 3.811 0 Td
[(were )-12(kept )]TJ
0 Tc 4.451 0 Td
(in )Tj
0.0303 Tc 1.047 0 Td
[(normoxic )-8(water )35(throughout )-2(and )]TJ
0.0455 Tc -13.353 -1.089 Td
(were )Tj
0.0303 Tc 2.502 0 Td
(undisturbed )Tj
0 Tc 5.527 0 Td
(by )Tj
0.0303 Tc 1.484 0 Td
(injection. )Tj
0.0152 Tc 4.451 0 Td
(Blood )Tj
0.0303 Tc 3.025 0 Td
[(samples )-126(were )-128(taken )]TJ
0.0606 Tc 9.076 0 Td
(at )Tj
0.0152 Tc -26.065 -1.06 Td
(timed )Tj
0.0303 Tc 2.647 0 Td
[(intervals )70(and )]TJ
0.0455 Tc 5.731 0 Td
(the )Tj
0.0303 Tc 1.571 0 Td
(time )Tj
0.0455 Tc 2.124 0 Td
(course )Tj
0 Tc 3.084 0 Td
(of )Tj
0.0303 Tc 1.106 0 Td
[(clearance )23(of )]TJ
0.0152 Tc 5.382 0 Td
[(a )-32(metabolite )]TJ
0.0303 Tc -21.673 -1.06 Td
[(load )116(from )18(the )]TJ
0.0152 Tc 5.876 0 Td
(blood )Tj
0.0303 Tc 2.589 0 Td
(followed. )Tj
/T1_3 1 Tf
0.0318 Tc 7.875 0 0 8.25 260.6396 468 Tm
[(Blood )-10(Sampling )]TJ
0.0476 Tc 7.406 0 Td
(and )Tj
0.0318 Tc 1.89 0 Td
(Preparation )Tj
0.0476 Tc 5.638 0 Td
(of )Tj
0.0318 Tc 1.128 0 Td
(Extracts )Tj
/T1_0 1 Tf
0.0909 Tc 8.25 0 0 8.375 269.7605 458.8802 Tm
(To )Tj
0.0303 Tc 1.425 0 Td
(withdraw )Tj
0.0152 Tc 4.247 0 Td
[(a )26(blood )]TJ
0.0303 Tc 3.375 0 Td
(sample, )Tj
0.0152 Tc 3.52 0 Td
(a )Tj
0.0303 Tc 0.844 0 Td
(I-mL )Tj
2.414 0 Td
(syringe )Tj
0.0455 Tc 3.316 0 Td
(was )Tj
0 Tc 1.891 0 Td
(fitted )Tj
0.0152 Tc 2.444 0 Td
(to )Tj
0.0303 Tc 1.076 0 Td
(the )Tj
0.0455 Tc -25.542 -1.06 Td
[(stopcock )83(and )]TJ
0.0303 Tc 5.993 0 Td
[(the )-36(stopcock )]TJ
0.0455 Tc 5.731 0 Td
[(was )38(opened. )]TJ
0.0152 Tc 5.673 0 Td
(Blood )Tj
0.0303 Tc 2.851 0 Td
[(drawn )-36(from )]TJ
0.0455 Tc 5.265 0 Td
(the )Tj
0.0303 Tc -25.513 -1.06 Td
[("dead )-269(space" )-283(inside )]TJ
0.0455 Tc 9.251 0 Td
[(the )-4(catheter )]TJ
0.0152 Tc 5.527 0 Td
(was )Tj
0.0303 Tc 1.949 0 Td
[(discarded )-95(and )]TJ
0.0152 Tc 6.342 0 Td
(a )Tj
0.0455 Tc 0.785 0 Td
(further )Tj
0.0303 Tc -23.884 -1.06 Td
(0.5-mL )Tj
3.316 0 Td
[(sample )95(was )93(withdrawn. )]TJ
0.0152 Tc 10.065 0 Td
(Blood )Tj
0.0303 Tc 2.793 0 Td
(was )Tj
0.0152 Tc 1.833 0 Td
(ejected )Tj
0.0303 Tc 3.229 0 Td
(into )Tj
/T1_4 1 Tf
0 Tc 6.125 0 0 8 452.64 432.2395 Tm
(1 )Tj
/T1_0 1 Tf
0.0152 Tc 8.25 0 0 8.375 457.2004 432.2395 Tm
(volume )Tj
0 Tc -23.738 -1.06 Td
(of )Tj
0.0152 Tc 1.105 0 Td
(ice-cold )Tj
-0.0286 Tc 8.75 0 0 8.375 300.2399 423.3604 Tm
(8% )Tj
0.0303 Tc 8.25 0 0 8.375 313.2004 423.3604 Tm
(perchloric )Tj
0.0152 Tc 4.596 0 Td
(acid )Tj
0 Tc 2.007 0 Td
[(in )10(40% )]TJ
0.0455 Tc 3.113 0 Td
(ethanol. )Tj
0.0303 Tc 3.724 0 Td
[(Precipitated )39(pro- )]TJ
0.0152 Tc -19.724 -1.06 Td
(tein )Tj
0.0303 Tc 1.891 0 Td
[(was )6(removed )]TJ
0.0152 Tc 5.935 0 Td
[(by )-72(centrifugation )-138(and )]TJ
0.0455 Tc 9.396 0 Td
[(the )25(extract )]TJ
0.0152 Tc 4.887 0 Td
(neutralized )Tj
-22.138 -1.06 Td
(by )Tj
0.0303 Tc 1.484 0 Td
(addition )Tj
-0.0152 Tc 3.927 0 Td
(of )Tj
0.0152 Tc 1.251 0 Td
[(3 )-34(M )]TJ
0 Tc 2.24 0 Td
(K,CO, )Tj
3.345 0 Td
(in )Tj
1.193 0 Td
(0.5 )Tj
0.0152 Tc 1.658 0 Td
(M )Tj
0.0303 Tc 1.367 0 Td
(triethanolamine, )Tj
0.0758 Tc 7.389 0 Td
(pH )Tj
0.0455 Tc 1.745 0 Td
(6.0 )Tj
0.0152 Tc -25.6 -1.06 Td
(\(Williamson )Tj
0.0303 Tc 5.353 0 Td
[(and )70(Corkey )]TJ
0 Tc 5.207 0 Td
(1969\). )Tj
0.0303 Tc 2.618 0 Td
[(After )98(centrifugation, )]TJ
0.0152 Tc 8.96 0 Td
(neutralized )Tj
0.0303 Tc -22.109 -1.089 Td
(samples )Tj
0.0152 Tc 3.665 0 Td
(were )Tj
0.0303 Tc 2.298 0 Td
(stored )Tj
0.0606 Tc 2.88 0 Td
(at )Tj
0 Tc 1.076 -0 Td
(-20\260C. )Tj
/T1_3 1 Tf
0.0318 Tc 7.875 0 0 8.25 260.8802 369.5999 Tm
(Metabolite )Tj
0.0635 Tc 5.029 0 Td
(Assays )Tj
0.0476 Tc -3.962 -1.076 Td
(Octopine )Tj
/T1_0 1 Tf
0.0303 Tc 8.25 0 0 8.375 269.0398 351.8405 Tm
[(Octopine )-408(dehydrogenase )]TJ
0.0152 Tc 11.753 0 Td
(\(purified )Tj
0.0455 Tc 4.276 0 Td
(free )Tj
0 Tc 2.385 0 Td
(of )Tj
0.0303 Tc 1.513 0 Td
[(lactate )-447(dehy- )]TJ
-20.887 -1.089 Td
[(drogenase\) )-208(from )]TJ
/T1_3 1 Tf
0.0318 Tc 7.875 0 0 8.25 324.9602 342.7196 Tm
(Sepia )Tj
/T1_0 1 Tf
0.0303 Tc 8.25 0 0 8.375 349.6805 342.7196 Tm
[(mantle )-219(muscle )-225(was )-197(prepared )]TJ
0.0758 Tc 13.382 0 Td
(as )Tj
0.0303 Tc 1.425 0 Td
(de- )Tj
-25.513 -1.06 Td
(scribed )Tj
0 Tc 3.316 0 Td
(by )Tj
0.0303 Tc 1.309 0 Td
(Fields )Tj
/T1_3 1 Tf
-0.0159 Tc 7.875 0 0 8.25 322.8003 333.8405 Tm
(er )Tj
0.0952 Tc 1.067 0 Td
(al. )Tj
/T1_0 1 Tf
0 Tc 8.25 0 0 8.375 342.4801 333.8405 Tm
(\(1976\) )Tj
0.0152 Tc 2.793 0 Td
(with )Tj
0.0455 Tc 2.095 0 Td
(the )Tj
0.0303 Tc 1.542 0 Td
(addition )Tj
-0.0152 Tc 3.724 0 Td
(of )Tj
0.0455 Tc 1.047 0 Td
(age1 )Tj
0.0152 Tc 2.153 0 Td
(filtration )Tj
0.0455 Tc -23.215 -1.032 Td
(step )Tj
0.0152 Tc 1.92 0 Td
(using )Tj
0.0455 Tc 2.473 0 Td
(Sephadex )Tj
0 Tc 4.334 0 Td
(G-200. )Tj
0.0303 Tc 2.996 0 Td
(Octopine )Tj
0 Tc 4.102 0 Td
(in )Tj
0.0455 Tc 0.989 0 Td
(the )Tj
0.0152 Tc 1.513 0 Td
[(blood )30(was )]TJ
0.0303 Tc 4.422 0 Td
(measured )Tj
-22.807 -1.032 Td
(spectrophotometrically )Tj
0 Tc 10.415 0 Td
(in )Tj
0.0303 Tc 1.28 0 Td
(an )Tj
0.0455 Tc 1.484 0 Td
(assay )Tj
0.0303 Tc 2.851 0 Td
(containing )Tj
-0.0152 Tc 5.062 0 Td
(100 )Tj
/T1_5 1 Tf
-0.0313 Tc 8 0 0 8.5 449.7605 316.5601 Tm
(rnM )Tj
/T1_0 1 Tf
0.0303 Tc 8.25 0 0 8.375 468 316.5601 Tm
(Tris )Tj
0.0152 Tc -25.076 -1.118 Td
(buffer, )Tj
0.1061 Tc 3.345 0 Td
(pH )Tj
0 Tc 1.833 0 Td
(9.0, )Tj
0.0152 Tc 2.095 0 Td
(2.0 )Tj
0.0455 Tc 1.513 0 Td
(mM )Tj
2.182 0 Td
(NAD+, )Tj
0.0606 Tc 3.695 0 Td
(lOmM )Tj
0.0455 Tc 3.316 0 Td
(EDTA, )Tj
0 Tc 3.724 0 Td
(100 )Tj
/T1_2 1 Tf
0.0411 Tc 9.125 0 0 7.75 453.3596 307.1997 Tm
(pL )Tj
/T1_0 1 Tf
0.0152 Tc 8.25 0 0 8.375 467.0398 307.1997 Tm
(neu- )Tj
-24.96 -1.118 Td
(tralized )Tj
0 Tc 3.811 0 Td
(blood )Tj
0.0303 Tc 2.996 0 Td
[(sample, )-294(and )]TJ
0.0606 Tc 6.138 0 Td
(100pL )Tj
0 Tc 3.375 0 Td
(purified )Tj
0.0303 Tc 3.84 0 Td
[(octopine )-281(dehy- )]TJ
-20.189 -1.089 Td
(drogenase )Tj
0 Tc 4.654 0 Td
(in )Tj
0.0152 Tc 1.106 0 Td
(a )Tj
0 Tc 0.756 0 Td
(final )Tj
0.0152 Tc 2.124 0 Td
(volume )Tj
0 Tc 3.462 0 Td
(of )Tj
0.0152 Tc 1.251 0 Td
(1 )Tj
0.0606 Tc 0.553 0 Td
(mL. )Tj
0.0152 Tc 2.124 0 Td
(Addition )Tj
-0.0152 Tc 4.044 0 Td
(of )Tj
0.0455 Tc 1.164 0 Td
(EDTA )Tj
0.0758 Tc 3.142 0 Td
(to )Tj
0.0455 Tc 1.164 0 Td
(the )Tj
-25.542 -1.06 Td
[(assay )187(for )]TJ
0.0303 Tc 3.956 0 Td
[(the )110(analysis )]TJ
0 Tc 5.091 0 Td
(of )Tj
0.0152 Tc 1.047 0 Td
(blood )Tj
0.0303 Tc 2.56 0 Td
[(octopine )98(concentration )37(was )152(found )]TJ
0.0455 Tc -12.655 -1.089 Td
[(to )1(be )]TJ
0.0303 Tc 2.502 0 Td
(necessary )Tj
/T1_1 1 Tf
0.1591 Tc 5.5 0 0 8.5 318.9595 270.7196 Tm
(\(J. )Tj
/T1_0 1 Tf
0.0303 Tc 8.25 0 0 8.375 330.4797 270.7196 Tm
[(Fields, )-42(personal )-75(communication\); )]TJ
0.0152 Tc 14.778 0 Td
[(this )-91(may )]TJ
-23.215 -1.06 Td
(be )Tj
0.0455 Tc 1.222 0 Td
(due )Tj
0.0758 Tc 1.774 0 Td
(to )Tj
0 Tc 1.076 0 Td
(high )Tj
0.0303 Tc 2.065 0 Td
(concentrations )Tj
0 Tc 6.545 0 Td
(of )Tj
0.0152 Tc 1.106 0 Td
(metal )Tj
0.0303 Tc 2.56 0 Td
(ions )Tj
0 Tc 2.007 0 Td
(in )Tj
0.0455 Tc 1.018 0 Td
(the )Tj
0.0152 Tc 1.571 0 Td
(blood )Tj
0.0455 Tc 2.589 0 Td
(extract. )Tj
-23.564 -1.06 Td
(Glucose )Tj
0.0303 Tc 3.811 0 Td
[(and )-105(lactate )-97(were )-70(measured )]TJ
0 Tc 11.985 0 Td
(by )Tj
0.0455 Tc 1.396 0 Td
(the )Tj
0.0303 Tc 1.658 0 Td
(methods )Tj
0 Tc 3.985 0 Td
(of )Tj
0.0303 Tc 1.193 0 Td
(Lowry )Tj
0.0455 Tc -24.029 -1.06 Td
(and )Tj
0.0303 Tc 2.066 0 Td
(Passonneau )Tj
-0.0152 Tc 5.556 0 Td
(\(1972\) )Tj
0.0303 Tc 3.055 0 Td
(and )Tj
0.0152 Tc 2.065 0 Td
(arginine )Tj
0.0303 Tc 3.956 0 Td
[(was )-226(determined )]TJ
0.0758 Tc 7.447 0 Td
(as )Tj
0.0303 Tc 1.425 0 Td
(de- )Tj
-25.542 -1.089 Td
(scribed )Tj
0.0152 Tc 3.287 0 Td
(by )Tj
0.0455 Tc 1.338 0 Td
(Storey )Tj
0.0152 Tc 3.025 0 Td
(and )Tj
0.0455 Tc 1.804 0 Td
(Storey )Tj
0 Tc 3.055 0 Td
(\(1978\). )Tj
0.1515 Tc -40.786 -1.691 Td
(bas )Tj
0.0455 Tc 2.153 0 Td
(advanced )Tj
0.0303 Tc 4.596 0 Td
(upstream )Tj
0.1515 Tc 4.451 0 Td
(fir )Tj
0.0606 Tc 1.774 0 Td
(5110cm )Tj
0.0455 Tc 4.044 0 Td
(and )Tj
0.0303 Tc 2.095 0 Td
(was )Tj
0.0152 Tc 2.153 0 Td
(stabilized )Tj
0 Tc 4.567 0 Td
(by )Tj
0.0303 Tc -25.804 -1.06 Td
(anchoring )Tj
0.0455 Tc 4.538 0 Td
(sutures )Tj
0.0758 Tc 3.345 0 Td
(to )Tj
0.0606 Tc 1.135 0 Td
(the )Tj
0.0303 Tc 1.629 0 Td
(connective )Tj
0.0455 Tc 4.945 0 Td
(tissue )Tj
0.0152 Tc 2.764 0 Td
(alongside )Tj
0.0455 Tc 4.305 0 Td
(the )Tj
0.0303 Tc 1.6 0 Td
(vessel )Tj
/T1_1 1 Tf
-0.0121 Tc 10.375 0 0 10.25 355.6802 216 Tm
(Results )Tj
/T1_0 1 Tf
0.0455 Tc 8.25 0 0 8.375 27.5999 203.28 Tm
[(and )43(the )]TJ
0.0303 Tc 3.433 0 Td
(ventral )Tj
0 Tc 3.258 0 Td
[(wall )-35(of )]TJ
0.0455 Tc 3.113 0 Td
(the )Tj
0.0303 Tc 1.6 0 Td
(siphon. )Tj
0.0606 Tc 3.433 0 Td
(The )Tj
0.0152 Tc 1.949 0 Td
(length )Tj
0.0303 Tc 2.88 0 Td
(of )Tj
0.0152 Tc 1.105 0 Td
(a )Tj
0.0455 Tc 0.756 0 Td
(catheter )Tj
0.0303 Tc 3.753 0 Td
(was )Tj
0.0349 Tc 10.75 0 0 10.375 270.9602 204.7203 Tm
(The )Tj
0.0116 Tc 1.853 0 Td
(effect )Tj
-0.0233 Tc 2.545 0 Td
(of )Tj
0.0116 Tc 1.049 0 Td
(hypoxia )Tj
-0.2326 Tc 3.527 0 Td
(On )Tj
0 Tc 1.228 0 Td
(blood )Tj
2.59 0 Td
(metabolite )Tj
4.532 0 Td
(levels )Tj
0.0455 Tc 8.25 0 0 8.375 27.5999 193.9197 Tm
(about )Tj
0.0606 Tc 2.735 0 Td
(80cm )Tj
0.0152 Tc 2.705 0 Td
(and )Tj
0.0303 Tc 1.862 0 Td
(terminated )Tj
0.0152 Tc 4.887 0 Td
[(in )-32(a )-61(light-weight )]TJ
0.0303 Tc 7.273 0 Td
[(stopcock )-53(through )]TJ
0 Tc 10.75 0 0 10.375 260.6396 193.2001 Tm
(is )Tj
0.0116 Tc 1.027 0 Td
(shown )Tj
-0.0465 Tc 3.014 0 Td
(in )Tj
0 Tc 1.116 0 Td
(Fig. )Tj
/T1_1 1 Tf
0.2131 Tc 7.625 0 0 10.875 338.3998 193.2001 Tm
(I. )Tj
/T1_0 1 Tf
0 Tc 10.75 0 0 10.375 349.4399 193.2001 Tm
[(Blood )-118(glucose )-111(levels )-141(declined )]TJ
0.0152 Tc 8.25 0 0 8.375 27.8405 185.0405 Tm
(which )Tj
0.0455 Tc 2.822 0 Td
(venous )Tj
0.0152 Tc 3.345 0 Td
(blood )Tj
0.0303 Tc 2.647 0 Td
(could )Tj
0.0455 Tc 2.647 0 Td
(be )Tj
0.0152 Tc 1.309 0 Td
(sampled )Tj
0.0455 Tc 3.782 0 Td
(and )Tj
0.0152 Tc 1.833 0 Td
(\(or\) )Tj
0.0303 Tc 1.804 0 Td
[(injections )80(made )]TJ
0 Tc 10.75 0 0 10.375 260.8802 182.64 Tm
(steadily )Tj
0.0581 Tc 3.617 0 Td
(during )Tj
0 Tc 3.059 0 Td
(hypoxia )Tj
0.1279 Tc 3.728 0 Td
(bit )Tj
0.0116 Tc 1.786 0 Td
(upon )Tj
2.523 0 Td
(return )Tj
0.0465 Tc 2.947 0 Td
(to )Tj
0.0116 Tc 1.273 0 Td
(nor- )Tj
0.0152 Tc 8.25 0 0 8.375 27.8405 175.9197 Tm
(without )Tj
0.0303 Tc 3.549 0 Td
(disturbing )Tj
0.0455 Tc 4.596 0 Td
(the )Tj
0.0152 Tc 1.658 0 Td
[(animal. )-148(Following )-83(a )]TJ
0.0303 Tc 8.873 0 Td
[(cannulation )-15(an )]TJ
0.0152 Tc 6.604 0 Td
(ani- )Tj
0 Tc 10.75 0 0 10.375 260.8802 171.5999 Tm
(mOxic )Tj
0.0233 Tc 2.992 0 Td
(water, )Tj
0 Tc 3.059 0 Td
(glucose )Tj
0.0116 Tc 3.572 0 Td
(concentrations )Tj
0 Tc 6.564 0 Td
(rapidly )Tj
3.349 0 Td
(in- )Tj
-0.0455 Tc 8.25 0 0 8.375 27.8405 167.28 Tm
(ma1 )Tj
0.0455 Tc 1.891 0 Td
(was )Tj
0.0303 Tc 2.007 0 Td
(allowed )Tj
0.0455 Tc 3.695 0 Td
[(to )-28(recover )]TJ
0.0606 Tc 4.8 0 Td
(for )Tj
0.0152 Tc 1.6 0 Td
[(a )-119(minimum )]TJ
0.0303 Tc 5.236 0 Td
(of )Tj
0 Tc 1.309 0 Td
(10 )Tj
0.0152 Tc 1.047 0 Td
(h )Tj
0.0303 Tc 0.873 0 Td
[(before )-67(ex- )]TJ
-22.487 -1.089 Td
(perimentation. )Tj
0.0455 Tc 6.807 0 Td
(The )Tj
0.0303 Tc 2.124 0 Td
[(animals )-149(showed )]TJ
0.0606 Tc 7.505 0 Td
(no )Tj
0.0455 Tc 1.542 0 Td
[(adverse )-143(response )]TJ
0.0758 Tc 8.058 0 Td
(to )Tj
0.0112 Tc 11.125 0 0 10.625 368.1595 160.5597 Tm
(the )Tj
0 Tc 10.75 0 0 10.375 426.4805 160.5597 Tm
(level )Tj
11.125 0 0 10.625 454.3198 160.5597 Tm
(before )Tj
0.0303 Tc 8.25 0 0 8.375 27.8405 149.0405 Tm
(surgery )Tj
0.0455 Tc 3.404 0 Td
(and )Tj
0.0303 Tc 1.774 0 Td
[(appeared )1(healthy )]TJ
0.0606 Tc 7.505 0 Td
[(for )175(at )]TJ
0.0303 Tc 2.502 0 Td
(least )Tj
0.0152 Tc 2.211 0 Td
(7 )Tj
0.0606 Tc 0.698 0 Td
(days. )Tj
0 Tc 10.75 0 0 10.375 260.4001 149.7601 Tm
[(gradually )-81(returning )]TJ
0.0465 Tc 8.104 0 Td
(to )Tj
0.0116 Tc 1.116 0 Td
[(the )23(prehypoxia )]TJ
0.0233 Tc 6.452 0 Td
(state. )Tj
0 Tc 2.523 0 Td
(Blood )Tj
ET
endstream
endobj
31 0 obj
<>stream
JFIF (B+(%%(Q:=0B`Ued_U][jxjqs[]gɺǙ(#(N++Nn]n
} !1AQa"q2#BR$3br
%&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w !1AQaq"2B #3Rbr
$4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz r ? 騢((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((()h(((((((((((((((((((((((((((((((((((((((((((((()(((((((((((((((((((((((((((((((()h(((((((((((((((((((((((((((((((((((((((((((((()(((((((((((((((((((((((((((((((()h(((((((((((((((((((((((((((((((((((((((((((((()(((zQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE-QEQEQEQEQEQEQERQEQA-QEQEQEQEQEQEQEQEQEQE%-f(fZLA4RE%-RQKEQEQEQEQEQEQEQEQEQEQEQEQE-QEQEQEQEQEQEQERQEQAQ1KEQEQEQEQEQEQEQEQEQEPhlO b֝M|ݛsҞi()E3E-&hQE(((((((((((((((((((()((((((((((((((((((((((((((((((((Z(((((((((((((((((((((((((((((((((((((((((((((((J((((((((((((((((((((((((((((((((Z(((((((((Ef((((EQEQEQEQEQE((((3EQEQEQEQEQEQEQEQEQEQEQEQEQEQEQKEQEQEQEQEQEQEQEQERQ()EQEQERIE-RQKIEQE-%-%RRRIKIKE%REQE%QE-%-RIKE%-QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQIEQEbQIKE\QE%-(JZ())h(J)h1EbQ(1E%-(QEb1EQEQEQEQEQEQEQEQEQEQEREQEQEQEQEQEQEQE%QEf(%-QE(QEQEQE((
QEf(QEQFhQ((J)i)h((((Q((((((((((((((()(()i(Z(ZJ(JZ)()EJ((ZJ(((((((())hZJZ(IKIKEQEQIKIKIE-%-QKEQEQEQEQEQEQEQEQEQ1F(bQ(bQJZ(bQb1F(bQF(RbQEQF(bQEQE4f(4QEf.h4fњ3E4fњ(4QEfEfњ(JZ3Fh()h((((((((3Fh(4QFh4RREQE%.h%.hQ(4fњ3Fhњ3IJhњ3Fi(4QERIE-QEQIEQKEQERQERRIKIEQKEQE-%-QE-QEQEQEQEQEQEQERQEQE%QEQKIKE%RQERQEQEQEQEQKE%QKIJ)((Z(((3EQEf3EQEFh(њ(3EQEQEQEQEQEQEQEQEQEQEQEQIEQEbQ1F(bQF(b1F(Q1F(bQ1Eb1F(1E(EQERQE-QE%RIKIKIERRIEQIE-%-%QE/jJ(Z(Z(((((((((44f3FhQ\fJ)h)3KCE.i)sFhQE43Fi)i)sFh%-fFh(Q(QE1EQ1F(QF(bRbZ({ъ1Eb(QF(bQF()h((((((((J()EJQE%P3@ϵ-)E%QEQKIEQJ)(ZJ(()i(REQIKERERQE-QERRi)sEQEQEQE%-
((RQKEQKEQEQEQEQEQEQEQEQEQEQEQEQEQEQEb1Eb(QEQEQEQEQEQEQEQIKEQEQEQEQEQEQERIKARQE-QEQEQKEREQEQEQEQEQEQEQE%QEfњ3IKJ\EfZ3ERњ(RRIKE%QAњJ)h4QFh3IKEQEfњ3Eњ3E4fFh(QK3IK(4fњ))sEQEf((((((((((J((4RQERRIEQKE%QEQKIEQEQE-(IERQERERQKIKE%-RERRE%-%REQE%QKEQIKIE-%QKEREQEQEQEQEQEQEQE%QEQEf(4fEQEQEQEQEQEQEb(((3EQEQEQ(((((((((EQEQE(((Z((((((((((()i)hJ((QE%QEQEJ(Z(J)h())h((JZ)(JZ(JZJZ((((((((()(((Z((()i(IEQEQE-JZJ(JQA((bQF(QEbQ1F(QEbQ1F(bQ1F(bQF(Q(Q1EQKEQEQEQEQEQEQEQEQEQEQEQEQEQEQFh()((EQEQA(QEQEQERQKEQE%(((QFhEQIKEQFh((((((((()(((()i((RQEQERQKIKA(QIERNQEQE-QEQEQEQF(((QF(%QIE-RQE-%-%
)())hZ(((((((((J\RQEQERQKJ((QE%-RR1IERQK@QK))hJZ3IKFhfњ))h4fQ(ҒQE4f))sGZJ\њ3FhQE%-%-QEREQEQEQEQEQEQEQE%QEfњ))h3Fh((EQEQEQEQEQEQEQEQE&ih((Z((J^QE-RQKIKIEQKIKIE/j)())hZ(((((((((IE-%REQJi((KIEQEQA((QEQE-%RQKEQEQEQERREQ3EQEQEb((((4QEf((Z(((((((((1EbQIKEb(Q1IKEb(QEJ)qEQ)1KEQERQE-QE-QKEQERv()i()h)((()h((((((((3FhQ3ERњ(3IKEf3AQERQKEf3EQFh%-QFh((Q1F(b1F(bQF(bQ1F))zъ1EbQ1F(Q(Q(1F(((((((((J((4QE(J(QIE-%QEQEQKڒ(()i)h())h((4Q(4QFh4f(њ(RRJZ((()h((((((((1F)(RRQ1F(QF(QF(%.(QF(bRRQE-QEQJ\Q(()h())h))h)())i)hZ)()i()h((((((((
%.hfRњ3E\EJ\Fh4RQKE%.h4fњ3EQ3E4fњ3Fh(3E%-())h4QFhfњ3EQEQ3Fhfњ((()h(((((((()(()EQKIEQERQEQEQKIEQEQKEQE%RQKE%QKFh))hJZ(J)hRQKڊ(JZJZ()hZ((((((((((QEQEbQF(1EQ(Q1Eb(1F((QF(Q1EQEQEQEQEQEQEQ3Fh(E4QEf(3ERREQEREQEQEQEQEQEQEQE%QEJZ(Q(4QFhfIE-&ihRv4PhIK3Fh4fFhQE%-RIKERIJ(Z(QE-QA)i)EQE%QKIKEQKEQEQEQEQEQEQEQEQEPi(QIEQE-J(()i((4RQERQEQERQKEQF((1IK(Rbb(QIK1F(b(b1F(QEbQ((((((((((J((QEQEQF((((QEQ((QEQEQF((()((IKER
\EQIE.h(4fJZ(4fREQEf()h((((((((
%QERRIEQFh-%-%-QFh3E4f)hZJZJ((QKE%-QEQ((()i((4Q(Z)(Z(((((((()((()i(((((()i)i(ZJ((QKڒQEQFh3E4fњ3Ef4f(4Q3F}3Fh4QIE4Q(QE-QEQEQEQEQEQEQERQEQE((E(Q((4f(QEQ(((((((RJ)i(IE-%R))i(J)i(Z
%RRIE-%REQEQEQEQEQEQEQEQIEQEQEQJi(4QEQERQEQEQERQE(J(SIEQKEQEQEQEQEQEQEQ(F((((((((((((((()((bQF)(Z
%-((RQEQEQKERQERQE-%-%(QERQKE%QKIE-&ii(Z()hJ)hZ(((((((((()(())h(EQEQEE(((((
QEf((J\Q(Q1F(QF))qF(QIK1F(bQ1F(bQ(b(bQF(QE-QEQEQEQEQEQEQERQEQE%QEQE(QJi((ZJ((((((IE((J)h(sE-QE%-QE%-f((3E())h))h((((((((J((bQ1F(b1F(b)qF((QERbRQKEQEQIK@(((())h(1EbJZ())i)i(ZJ(J)h)h(((((((((f(QEPh((QEQFh(4QEQEQEQ((4RQK3EQ3EҊ3Fh(((((((((((((((((J((4QEQKE%QEQE-QKE%J((QE%QER
%QE()(4QE%RERR)((((((((((((((((((J((bQ1F(bQ1F(QF((1F)1K)1K@Q1F(LRъ((((((((((((((((((((((((J((4fE(Q3Ef\њ))sFhњJ\њ(4f))sFh4Q3EQEf3Fh((((((((((((((((((((((()(((J(4Ri(((4QEQER
%RQEQEIEQJ(EQE(EQEQEQEQEQEQEQEQEQEQEQEREQEQEQEQEQEQEQE%QEQF(bQF(Q1F(bQ1F(Q(bQ1EQ1F(Q1F(bEbQERQEQKIE-RRRIEQERREQEQEQEQEQEQEQEQE-QEQEQEQEQEQEQERQEQE4Rњ(RR撗4Q\њ(4f3I\њ3Fh4Q))sFhfњJ\њJZ3Fh4QEQIZ(QF(QEbQF(bQ1EQEQEQEQEQEQEQEQEREQEQEQEQEQEQEQE%QEJ()hZJ(((()h(QERQEQE-QEQFh4fњ(4fE%.hQ(t4fњ3Fh44fJ\њ(.h((((((((J((3EQ((b1EQ1F(QF(Q(b((QEb1EQERRQERQFhZ)(ZJ(()i(-%-%-QE%REQE-QEQEQEQEQEQEQERQEQEQIKIE-IKFhRR3IK(4RRh3EQ(IKIKFhњ(3EQEQEQEfP(3E((3EQEQEQEQEQEREQEQEQEQEQEQEQE%QEQE%J(4QEJ)i()i()i((()EQE()(JZ(J)hZ()(J)h((J)h((((((((J((((f(((@(QEQEQEQEQEQEQEQEbQF((b1EbbQF(b(QF(b(QEQEQEQEQEQEQEQEQIEQE()M%QEQKEIKIKIE)(Z
QEQEQE%RIKE)(JZ))hJQIE)((JZ))h(JZ((((((((()((QEQE-%QEQESE%QE)(Z)((()hJZ(1F(Q1EQEEQ(bQ1EQEQE((QEQEQEQEQEQEQEQEQIEQEf((4QEQEQEQ((((EQEQEQEQEQEQJ\њ)(4f3E\Rњ3FhњJ(4f(IKJ\њ)(4
3EQE-QEQEQEQEQEQEQERQEQEQERJ((SIEJ(()i()i(Pi()M%REQERJ(3KJ)h)h)hJ(Z((((((((((J((bQ1IE-%)Z
Z(J(QE%-RJ)i(())h(3Fh(EQfQEQEb(((LEQKEQEQEQEQEQEQEQEQEQ(4RP)M))EQE(((њ(Ef(((((J)i)i(RQKIKIE-R)(RRi((E%-QKEQE-QEQEQEQEQEQEQERQEQE%QEQKE%(ZJSIEQEQKIEQEQERQEQE((QF(QEQEb(Q(4bQF(QAK(Q(bQEb1F(((((((((J((bQ1F(Q1GJJ\Q1F(b))h%-%-1E%QIK(b1F(QEQEQKERQE
J((4QE-%RJ(ZJZ())h(Z(((((((((J\њ3EQEFh(3Fh4fFhE
(MQE4
3FhQE((QF(1F(bQ1ERR1F(b1F(Q(((4QEQE-QEQEQEQEQEQEQERQEQE%QKER
%QEQKERQKIEQE
%QEQEQERi(3Fh((@њ
Fh\њ3@њ(%.hfFh(Q()h((((((((1F(bQF(1F(bQ1EQF))qF(bQ1EQF(QIKEbQEQERQE())hQE%()(4QE%Ph)h(QE%-QEQEQEQEQEQEQEQEQIEQE%fњJZ3Fi3K(%.hFhRR3Fh4QEQ(4ff(4f3Fh4f(((((JZ(((3EQE(((((((((((()(((SIEQEQJ(4QERQER
%QKIEQJ(RRQKE)ERRIKIKEQERERRJZ(QEQKE%-%-RQEQERQKIE-QKEQEQEQEQEQEQEQEQEQEQEQEQF((Q1F(1F((Q1F((QEQ(:EQEQEQEbRRb(bQ1EQ1F(b(bQ1F(bQEREQEQEQEQEQEQEQE%QEQE RR3Fh%.h%f3IK3Fh&h44RQK(IK(њ3@њ3IKE((RRQKEQEQEQEQEQEQEQEQEREQEQEQEQEQEQEQE%QERQEZJ(()i(((J(Pi(RQEQKA)i((Q1Eb(bQF(Q(bQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQIEQEQEQE(1EQEQEQEQEQE(((1EQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEREQEQEQEQEQEQEQE%QEQEQERASIKIFh3IERRQFih4fJ)h%IE!4QEfEQj(3EQE
3EQEQ(3Fh(((((()h(((((((()(((QE))i((ZJ(ZJ(QERJ(()h)i)i(QI(RQEQEQJi1KIEQE(((((Z((((((((((((EQEQ(EQEQEQEQEQEQERREQERbQ()h1F(b1F(bQ))hbQ1EQEQEQEQEQEREQEQEQEQEQEQEQE%QEQ((()h)h4QJ(((()hQE%QE((4QFh4u3Fhњ(%.h4P(fH)sFhEQEQEQEREQEQEQEQEQEQEQE%QEQ1Eb((()EQE-%((RQKE%REQE%RRQKIJ)(())hQE)\IE))hZ(((((((((((QEf3EQ((((((QEQEQ3EQEQEfњ3Fh4f:QEQ3EQ(EQEQEf(4QEQEQEQEQE-QEQEQEQEQEQEQERQEQE%-%Ri()i()h4QEQEQJi((QERQJ(4REQIKIKERRIE-%-RQKIKIKIJi)i)h))i((Z(QE%-QKEQEQEQEQEQEQEQEQEQ1F(b1F(Q1F()(RQEIEQ)i(IE-Z((((EQE4QEQ((((QIKE1EQE-QEQEQEQEQEQEQERQEQFh4fREEf(3E3AQIKEQE(4f(3Fhf3Fh(Z
%RR)(JSIKE%QJi(QIEQE))h4QIE-%REQEQEQEQEQEQEQEQIEQE%QEQERi((()EZ)(((()i((QERREQF(b(QF(bQF(1F(b1F((Q(QEREQEQEQEQEQEQEQE%QEbQ1F(QEbQ1F(bQ1F(Q1F(Q1E%.))hQ(bb((4f(4fEQ3FhQ3E))sFhњ3Fi
4((4QEQE-QEQEQEQEQEQEQERQEQE%.hJQAJ\f43FhRKFh4f(3Fi)sFh4fњ(Q3Fh)()(QIE4QEQFh3EQEQ@Z)(4
J(QE-QKEQEQEQEQEQEQEQEQEQIEJZ
%RQEQJ()M%QEQE-%RQE(((J(3IJhњ(QKFhE-fR)((3FhRњ3Ef(((((((((J((bQ(bQ(QF(Q1EbQ1F(b1F(bQbQ1@Q1ERRQEQKERQGz((((ZJ\IEQE-%RQE-QE-QEQEQEQEQEQEQERQEQFh4RFh4QK(4f(4RR
%.h4fњJ\њ((4њ3Fh((((
((4QE((QEQEb(JZ((((((((()((((J((QEQER
%QEQE(QEQKE%QE-QIE(Z))h)h(ZJ)i)i)hZJ(ZJZJ(((((((((J(((QEQEQF(QEQ1EbQ1Eb(bQEQF((((QE%QF(QF(bQ1F(b(Q1EQ1Eb1F(((((((((()(()hJZ3ERRњ(%њJ)sEJZ(4Rњ))sIKEfE%4(QIKE%Ph))h())hEP((њ(((JZ()h(((((((()(ZJQIE-%RQEQE)(IEQE-%QERIEQERERREQEQEQE(Q@(QERQERQKIKIE((((((((()((EQEfEQEQE(((QEQF(((JZ((J)i)sFh4fњ3E%3FhJ1KAE.h4fњJ)sFhQ(4fRRњ(((((((((J()(QA(((ZJ)i((E%RQEIKEQEQE%-RRE%.i(Z(RIKEQE%-QERRQKE%-QE-QEQEQEQEQEQEQERQEQEIKERQJ)((()i((()i(4QEQEQEQEQEQEQ3Fi)h(((QEQEQEQEQEQEQEQEQEQEQEQEQIEQE((4QFh
QEQE&ih((((3EQFh(()(ZJ(((((((((((((((((((J())i((ZJ(QIJ(4QERQEQERRQERQE-(QKEQF)(Q(bQ1F(QF(bQEQEQEQEQEQEQEQEQE-QEQEQEQEQEQEQERQEQF(bQ1F(bQEQEQKIEbJ)h(QIE-)(IE-QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE-QEQEQEQEQEQEQERQEQEfERE(((QE(((((EEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEREQEQEQEQEQEQEQE%QEQEQERJ(((IEQEQERi(((((4Rњ(4fњ3EQEQEQEQEQEQEQEQEQEQEQE-QEQEQEQEQEQEQERQEQF)1K1F))qF(Q1F(bQ1F(bQ1F(.))qIEEQ(bQJ)qF()()i)i)i(Z((((((((((()h((((((((J\gڗ4QEf3FhJ)h4QIJh4QIKEQ(4RRњ(((4QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQKEQEQEQEQEQEQEQEQEQIEQE)(IEQEQKIE()i((((QEQEQKEQERQE-QEQEQEQEQEQEQEQEQEQEQEQEQKEQEQEQEQEQEQEQEQEQ1EbQEQ1EbQ1F(RREb1EQF(.(&(1F(bQ1F((1F((((((((((((((Z(((((((((IEњ3Fh44fRњ(RQKIK3E%-4f3EfFh4QFh4f3EQEQIE-%-QEQEQEf(њ))h((
QE%-QEQEQKEQEQEQEQEQEQEQEQEQIJ)(ZJ((((ZJ()i(()i(J((QEQIKEQEQE%-RQKEQERRE%-RRR
%(QE-RQE-QEQEQEQEQEQEQEQEQIEQEQEQEQ1F(bQ1F(Q(bQ1F(QEbQ(QF(bQ1EQFh4fњ3EQ3FhRR3FhFh4f(4f(4f3Fh(QEQEQEQEQEQEQEQEQEQIEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEJ)i((QKA(RQKIEQIK@E%REPi)h4QEREQEQEQEQEQEQEQE%QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE((((њ3FhQFhEQFhQEQEQ3Ef(((((((((J((((()(4RR撗4RfRQE.i)hQEQEQEQEPi(QIE(ZJZJ)i)h)i()()hZ((((((((((J((((()((((J((Z(((((Q1F(b1EQ1F))EQF(Q1EbQEQEb1E%-bQ((((((((()(((((((QE(b(bQF(b(((((J)i)i(J)i((ZCE-QIKE(())h(((((((()((4f3EQERR(4QEQEQEQEQEQEQEQEQEQEQARRF(Rw(b1F(b(QEQEQIE-RIKIKEQKEQEQEQEQEQEQEQEQERQEQEQEQEQEREQEQEQEQEQEQEQEQEQEfEfEFh4QEQ(4fњ3Ef(JZ(EQEQEQEQEQEQEQEQEQIEQEQ3EQEQE%-QE((((((((4QEQEJ(ZJ(((J)i()h)h))hJ)h)h(((((((((QEQEQE-)i((IKIE-%J(J((QIEREQEQފ(((:QEf())hEEQFh(((((((((()((1F(bQ1F(bQ(QJ1KJZ
JZ))h-1EQF(1E())h((Z(((((JZ((((()h((((((((J)sE%-%.hRQK(%-(RRRR(њ3IKJZ(4fњ3FhQER(b(b1F(bQEQEQEQF(1EbQEQE((((((((()((((((J(((((((IER())h(4f(4fњ(3EQEQEQE4fEQEQEQEQKEQEQEQEQEQEQEQEQERRњ(((QEQE'zQEQ(3Fh(8((((((IEQE-)ERQKIKE%-QIE-QKIKIJ(Z()h((((((((J(RQEQKFi((J-%-%QEQEQEQEQERRQE((4fњ3EQEQE(QFhQފ())sEQEQEQEQEQEQEQEQEQEQEQEQEQIEQEQFh1EQE(QEQJ\RQK1EbQ1EQJ\QEQF(QF(
RQEQERQEQKIKE%RRњ(())i()h((((((((J((QEQE()i(QEQERJ(((J(((((((((((1F(((J)h((((((((J((bQ(b1F(QF(Q(QKF)(SIKIE.(RRF(bQ(IEQKIE-QEQEQKIKIF)i(QEQEQEQF(ZJ(((((((((()(((Q3Fi)sFi3KIE袔QIKE%-ERRIEQKIER撖њ3FhQEbRR1E(QJ\Q1F(b1F(bJ\Q1F(bQ(Q(QF(Q(Z(((((((((ZJ((((((((Z)(ZJ()i(((4Q(E3FhQIKIKEQ3Fhf(3Fh%(4QERE(Z(((((((((њ3Fh@(((IK(((4QE(8(((IKE%-%QKIE(J(J()h(()hJZJ(((((((((J()((RQEQE-QEQE-QJi((QERQEQEREf(4fJZJZ(f(4QEQEf3EQEQFh((EQEQEQEQEQEQEQEQEQIEQEQEQEQEQEQEQEQEb(b1F(bQ(QF(QF(((J(((Z(JZJZ(JZ)(JQEQKEQEQEQEQEQEQEQEQERQEQERRQE-%QERQEQE-%QERRQKIEQKIE-QEQEQEQEQEQEQEQEQFh(((1EQEQEREQEQEQEQEQEQEQE%QEb1F(b1Eb(1F(QF(()1KEQIKEQIK(Q(()i)h)(ZJ(J(1E-RRIEQKE%-%-QE%RREQEQEQEQEQEQEQEQIEQE4fњfFhњ3E%QE-Pi(I\Fi)Ef3E4fњ3EQ@њ3EQE&)h(((b1F(Q1F(bQEQF(bQ1F(1EQ1F((((((((()((((RQEQEQK@)E(Pi(QIEQEQKA)h((4Q3E4RRRRFhQ3E%-QE4QEQEQEQERREQKEQEQEQEQEQEQEQEQEQJ\њ3Fh%Fi)hf((4(QFh4QA4QFh(((((J)i()h4Ri((4f)MRJ((IKE%QEQEQEQEQEQEQEQEQIEQE%QEQEQKIEQEJSIERi((R)(RQERQE-QFh%4QFh4fњ(QE4fIEQKEQEQEQEQEQEQEQE-QEQEQEQEQEQEQERQEQEQEQEQEP(1EQEb(b1EQF((1EQ1E))h((ZJ)i)h)h((((((((((((((J()(((()i((((SIEQKEQJi(((((QEQEQEQE((((((((((((((((J())qF(bQ1F(b1F(bJZ(QEJ1KE(QLR(((((((((((((((()h((((((((3FhRFh
(fFh4RRRRњ(њJZJ3K(J(f(4f((((((((((((((((Z(((((((((IE((QEQERQKIK))i()h4RIEQERi((((((((E%-QEQEQEQEQEQEQEREQEQEQEQEQEQEQE%QEfњ(4f(f(E((EQ(4QFh(QEf((((((((((((((((Z((((((((((((ZJ)i(((((((ZJ(((((((((((((((((((((((((J(((QF())h(1EQ(QF(Q())qEQEQF(QEQA(QEf(fFhњ(3Fhњ3Fh3EQEfњJZ()h((((((((J(SIEQE-%RQERQEQKERQERJZ((SIEQEQE%RREQEQIE-%-QE%-%RR)()h)h((((((((1F(bQF(bQF(b1F(RRIE(E%-%RREQEbQF(4b1EQEQEQEQEQEQEQEQEQF((QF(Q1F(QEb(Z(((((((((RfZ3EQIKIҗ4fJZ3E%RFi(Z3Fi(ZLK(4fњ3EQEQEњ(J)sEQEfEf4fњ3FhFh()(()h((((((((J(QIEQKIEQEQERQE-%RIEQKIEQERQEQE-RQJi)i((J)sEf))i)i)h)(QIE-QEQE-%-QE-QEQEQEQEQEQEQERQEQFi(QFh4fAFh3EQFh4fIK3E4fLҚ))sFh4QFh((QEQEb(((4Q(((((((((((((((J()((4QERQEQEQKIEQEQE-%RQE-%QEQJ)()h(Z))i)h)EQEQEbRIEQE-%QKIE-QIEQEQEQEQEQEQEQEQEQIEQEQ3EQFhQFh)3KE(u))hQ(bQE%-Q(((J(ZJQERRQK@JZJ(()i3EQKEJZ)3EQEREQEQEQEQEQEQEQE%QEQEQKIEQEQERQEQKE%QEQERQEQEQJi(4REQEQE((Q(QEQEQEQEQEQEQEQE((((((((()((Q1F(Q(bJZ1F(bQ1F(1IKEQIKIZJ()i)qEbQE(J)hJ)hJ)i(RQEQERQERIERIJ(4QEQE-QEQEQEQEQEQEQERQEQEfњ3E4QIJhQ3Fh4fJ\ERQEQEZJ)h)h4fEQEh(1EE%-QE
(JZ))h(Z((Z
%-QEQEQEQEQEQEQEQEQIEQER
RJ((4QEQKIE(((4JZJSIEQJ)((((QEQEQEQ@(4QEQEQEQEQE(((Z(((((((((њ3IK3FhFh))h((њ(f(4Q3Fhњ3Fh4QFhQIKE%RREQIKEQEQEQE))h()((QEREQEQEQEQEQEQEQE%QEQEQEQERQE((QE%QEIE)(ZJ((RQKEQEQE1E1EQ(P(Q(Q1F(QF((1EQEQEQEQEQEQEQEQEQEQIEQE((EQEQIKE%-QE(((Q1E(Q(QE4fREњ3Fh44f(JZ3EEf(EQEQA(QEREQEQEQEQEQEQEQE%QEQEQJi(((EQERJ(((QEQEQEQEQIERRE(())zE%QE袊SIKE%))i(((((((((J((bQ1IEiqF(bQ1F(%-(1F(b\Rb((((F(b1F(Q1F(bQ(bPi)qE.(b1F(QEbQ1EQKEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQIEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQKEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQIEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQKEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQIEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQKEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQIEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQKEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQIEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQKEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE
endstream
endobj
30 0 obj
<>/Type/XObject/Width 1912/ImageMask true/Length 99620/BitsPerComponent 1>>stream
:8ȜXM4{MS;F>9 &}ޒ:)"!&jR*)ᙌBT3aHj=*ahR 40U Cѭ D0#{E $äZmvi {P&o$=>l:IiץJƿAuOS4M[z8R<=I&m%o
/IomUkI^:_Kzkz#zTq_F
#]=uΎQJҴ0 rKB%J"">FP]~Qi=js-#TNori+kMk_ Xa%VI~H|R0K+a1Cb)'_
", ePB4""!Db""#Tdu;+Ÿړ;`sfE2 &L?\PMBb]
\CB!wvݦaw\zߔZw_J B(gdRzV]d\Dl d1fmƦE>GL<@dy.~r='ddcSќf3lmn FBALA4x۰L.P0T38<3CB0;043C 0a ]pB3 a0@5NI>=H6ywFƍd,",8t\4lxE8D܉b.EaajJ)Xm]_ꪖH
[}d$Oh 'Ez /A6N7Mmzm'ؕ2wK t~&yI %'K2Y},uYfKV*Z'i%Nc u]:}7O VIt?oUU*T='0'{4Ez^|$t.u?hMJI*^UszB %VCk/tju]m7__i'HI--W^_kGZK{ZZZxo+wҤ&G爹+0P([:h*ZID.{}-lӿڿm34lϵLB j!4B-0
+Z_ 6ok!}k)KPB"""#ۦհTmW[د_%IKf,1҆M5V 17j!Zv5iZm1ZiQ ;
بA'a0Nm'm' ;M5Njby|IUHANX*a&kMY+ Xi5M4h00
iҬhDGDDDDDDDDEI}\D~.WX0ӨAàBQm8y+ʮdĢj#GiL)٩`K8aûWq),ZoW_^*q@Ӛdѝo\.@ mfejH dA&'0>as3`Aa h`1HJw__Zoi#sXEwv5Z.Ztl>dl--in.(ѱ4]\;]}Kߏ/Km_,wvG mXdWӠò;6jۤ>M aAAImA7";;M_/װE<_抾\Vn~;MnOo\wd~J֒t; _aV{]7Oo_Vin߿_Xa+WKثS/~~ߦ_]K[HvֵX ״jLlpx]Mxz=Y^+ƾbMݫcNm/iBA7aOidnov'#zpzuiM&6:d&N't"¦ Aja20CD< »xDC L&_oWo3,B,gDDDDDDDDDDDDDDDD~>?m+VE7=u co
qULU6H^P{jg٧}M]j9}vK[_ZaGun~Jx)튆 }mvUCkjKҰUbqN9Cv":i0ZqM2#O݊ zp I44iZG;LRiҧa m'aXL3O aL]+4a,'i -XAXPDD8B"" z*;Y3%j)ε%gtx@N)ۊxB%x)v}FvQxi ;'_w*ڤ$V(ssuW:%:OՅOZ_M8)\.e䬂<$38mffly33$b3#H.w\2 ͑ˣA.g5ʍ!a({Q
a
д#[!P%8!a3~DlRv:H5oF$h~ޒ
pfhz_MrN-}dJ/ƕI7v[K>̈́VO5\&?^oz}_ߤtZW9pp__k~i;w[+ggjm;Bf>j
Sq_nn]zW!$ӵ[iw_ `+:]|ci)#o۬/IG?˯RoiN?"o~qZ/
A^?p!uP7_k*"$Ne"%,dJ:aƸʰ{)wo$Bk%`0E./R.d{Ko{VݳO_SM46J/ۯ+MVGG~K